60 inch male patient - 50kg and 60 inch female patient -Ĥ5.5kg. The baseline method starts with the initial ideal body weight baseline At 38 inches for a male, and 40 inchesįor a female, the IBW is ZERO. Inches, the result is reasonable, however, 2.3 kg/inch is excessive when IBW (Female) = 45.5kg - 2.3kg for each inch below 60 inchesĬomments: For patients just a few inches below 60 IBW (Male) = 50kg - 2.3kg for each inch below 60 inches Not changed or added any new methods for estimating an ideal body weightįor patients less than 60 inches tall. A quick review of the recent literature has Output of this section is based on research I had completed ~20 yearsĪgo on this subject. Weight is less than any of the calculation methods, the actual body 1916 17:863–71.īackground info for height less than 60 inches A formula to estimate the approximate surface area if Estimation of creatinine clearance when urine cannot be Whose actual weight is significantly greater than their IBW. Ideal body weight (IBW) or an adjusted body weight (ABW) in obese patients However, the most commonly used version of this equation incorporates the The original Cockcroft and Gault equation utilized total body weight, Male: CrCl (ml/min) = (140 - age) x wt (kg) / (serum creatinine x 72)Ĭockcroft DW, Gault MH. Previous exposure to chemotherapy or radiotherapy, and overall healthĮstimated Clearance Equations Cockcroft and Gault equation: Additional factors that should be assessed include: obese or cachectic patients).Ĥ) The package insert does not provide a specific formula for GFRĥ) AUC-based carboplatin dosing is more accurate than dosing according toĦ) Several factors must be considered in addition to the GFR to determine Unreliable results may be obtained in patients whoĪre outside the normal weight range (e.g. Kidney function (creatinine clearance below 15 mL/min) are too limited toĢ) Fluctuating serum creatinine values DO NOT provide an accurate CrClģ) GFR estimation: Definitive guidelines or method of determination has notīeen firmly established. Package insert: The data available for patients with severely impaired Platelets Neutrophils Adjusted Dose* (From Prior Course)ġ) The use of the Calvert formula in patients with a GFR or CRCL less thanġ5 to 20 ml/min is not recommended based on insufficent accuracy. Lowest post-treatment platelet or neutrophil value. Trials in previously treated and untreated patients with ovarian carcinoma.īlood counts were done weekly, and the recommendations are based on the Or combination therapy shown in the table below are modified from controlled The suggested dose adjustments for single agent Status are important prognostic factors for severity of myelosuppression in Target AUC of 7 (range: 6-8) mg/mL per minute has been recommended whenĭose Adjustment Recommendations: Pretreatment platelet count and performance
Multi-clearance output should help you make an informed decision in determining In a few test patients the calculated carboplatin dose wasĬonsiderably higher with this new method. Potential for significant disparity in dosage compared to conventional clearanceĮquations. After reviewing several test patients, there is Based on new research (see below), the CKD-EPI equation (corrected for BSA) was added as anĪdditional clearance equation.
0 kommentar(er)
